| Event | Venue | Date/Time | |
| Missouri Southern State Lions vs. Midwestern State Mustangs | Fred G. Hughes Stadium
Joplin, MO | Saturday
8/30/2025
TBD | view
tickets |
|
| Missouri Southern State Lions vs. Northwest Missouri State Bearcats | Fred G. Hughes Stadium
Joplin, MO | Saturday
9/20/2025
TBD | view
tickets |
|
| Central Missouri Mules vs. Missouri Southern State Lions | Kennedy Field At Audrey J. Walton Stadium
Warrensburg, MO | Saturday
9/27/2025
TBD | view
tickets |
|
| Missouri Southern State Lions vs. Fort Hays State Tigers | Fred G. Hughes Stadium
Joplin, MO | Tuesday
10/7/2025
TBD | view
tickets |
|
| Emporia State Hornets vs. Missouri Southern State Lions | Welch Stadium
Emporia, KS | Saturday
10/11/2025
TBD | view
tickets |
|
| Missouri Southern State Lions vs. Washburn Ichabods | Fred G. Hughes Stadium
Joplin, MO | Wednesday
10/15/2025
TBD | view
tickets |
|
| Missouri Southern State Lions vs. Nebraska-Kearney Lopers | Fred G. Hughes Stadium
Joplin, MO | Saturday
10/18/2025
TBD | view
tickets |
|
| Missouri Southern State Lions vs. Missouri Western Griffons | Fred G. Hughes Stadium
Joplin, MO | Saturday
10/25/2025
TBD | view
tickets |
|
| Pittsburg State Gorillas vs. Missouri Southern State Lions | Carnie Smith Stadium
Pittsburg, KS | Saturday
11/1/2025
TBD | view
tickets |
|
| Pittsburg State Gorillas vs. Missouri Southern State Lions | Carnie Smith Stadium
Pittsburg, KS | Saturday
11/1/2025
2:00 PM | view
tickets |
|
| Central Oklahoma Bronchos vs. Missouri Southern State Lions | Chad Richison Stadium
Edmond, OK | Saturday
11/8/2025
1:00 PM | view
tickets |
|
